MovDisordV3, Main, Exploration, bibRecord, 003C13

Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism

Identifieur interne : 003C13 ( Main/Exploration ); précédent : 003C12; suivant : 003C14

Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism

Auteurs : Thomas Foltynie [Royaume-Uni] ; Terry E. Goldberg [États-Unis] ; Simon G. J. Lewis [Royaume-Uni] ; Andrew D. Blackwell [Royaume-Uni] ; Bhaskar S. Kolachana [États-Unis] ; Daniel R. Weinberger [États-Unis] ; Trevor W. Robbins [Royaume-Uni] ; Roger A. Barker [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2004-08.

RBID : ISTEX:505498BFBE6597DF2E86C2B897D42C5E6ECDA26C

Descripteurs français

Pascal (Inist)
- Aptitude, Parkinson maladie, Planification, Polymorphisme, Système nerveux pathologie.

English descriptors

KwdEn :
- Ability, Adult, Aged, Amino Acid Substitution, COMT, Catechol O-Methyltransferase (genetics), Concept Formation (physiology), Demography, Female, Genotype, Humans, Male, Methionine (genetics), Middle Aged, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (genetics), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Planning, Polymorphism, Polymorphism, Genetic, Valine (genetics), cognitive, phenotype, polymorphism.
MESH :
- chemical , genetics : Catechol O-Methyltransferase, Methionine, Valine.
- genetics : Parkinson Disease.
- physiology : Concept Formation.
- physiopathology : Parkinson Disease.
- Adult, Aged, Amino Acid Substitution, Demography, Female, Genotype, Humans, Male, Middle Aged, Neuropsychological Tests, Polymorphism, Genetic.

Abstract

Parkinson's disease (PD) patients show a range of executive deficits involving dopaminergic transmission in the prefrontal cortex. In this study, we have investigated the impact of catechol‐O‐methyl‐transferase (COMT) val158met polymorphisms on performance of the Tower of London (TOL) test of planning by PD patients. Motor and cognitive assessments were performed on 288 patients as part of a population‐based study of PD. These patients were subsequently genotyped for the COMT val158met polymorphism. Patients with high activity COMT genotypes performed significantly better at the TOL task than those with low activity genotypes. Subgroup analyses suggest that this effect is greatest in patients exposed to dopaminergic agents. We hypothesise that the inferior performance in patients with the low activity COMT genotype is attributable to a state of relative hyperdopaminergic activity in the dorsolateral prefrontal cortex compared with that in the striatum. We suggest that polymorphisms of common genes, which regulate central nervous system dopaminergic transmission, can influence some of the phenotypic manifestations of PD. © 2004 Movement Disorder Society

Url:

https://api.istex.fr/document/505498BFBE6597DF2E86C2B897D42C5E6ECDA26C/fulltext/pdf

DOI: 10.1002/mds.20118

Affiliations:

Le document en format XML

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<term>Adult</term>
<term>Aged</term>
<term>Amino Acid Substitution</term>
<term>COMT</term>
<term>Catechol O-Methyltransferase (genetics)</term>
<term>Concept Formation (physiology)</term>
<term>Demography</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Methionine (genetics)</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Planning</term>
<term>Polymorphism</term>
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<term>cognitive</term>
<term>phenotype</term>
<term>polymorphism</term>
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<term>Aged</term>
<term>Amino Acid Substitution</term>
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<term>Genotype</term>
<term>Humans</term>
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<term>Middle Aged</term>
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<term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) patients show a range of executive deficits involving dopaminergic transmission in the prefrontal cortex. In this study, we have investigated the impact of catechol‐O‐methyl‐transferase (COMT) val158met polymorphisms on performance of the Tower of London (TOL) test of planning by PD patients. Motor and cognitive assessments were performed on 288 patients as part of a population‐based study of PD. These patients were subsequently genotyped for the COMT val158met polymorphism. Patients with high activity COMT genotypes performed significantly better at the TOL task than those with low activity genotypes. Subgroup analyses suggest that this effect is greatest in patients exposed to dopaminergic agents. We hypothesise that the inferior performance in patients with the low activity COMT genotype is attributable to a state of relative hyperdopaminergic activity in the dorsolateral prefrontal cortex compared with that in the striatum. We suggest that polymorphisms of common genes, which regulate central nervous system dopaminergic transmission, can influence some of the phenotypic manifestations of PD. © 2004 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism

Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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